سامانه همایش های دانشگاه آزاد اسلامی واحد نجف آباد

صفحه اصلی / اولین همایش بین المللی تحول خدمات سلامت: تلفیق مراقبت، درمان، بازتوانی و امیدبخشی

The role of ACE2 gene polymorphisms in the development of hypertension

نویسندگان :

Farzaneh Jafari¹

1- دانشگاه ازاد نجف اباد-دانشکده پزشکی

کلمات کلیدی :

Hypertension،gene polymorphisms،ACE2،renin-angiotensin system،single nucleotide polymorphism

چکیده :

Background: Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system and is an essential target for the prevention and treatment of hypertension. Angiotensin-converting enzyme 2 is an enzyme with 802 amino acids that is located in the cell membranes of the lungs, arteries, heart, kidney, and intestine 1. ACE2 genome shows a high degree of polymorphism. ACE2 single nucleotide polymorphism (SNP) is associated with blood pressure in Europeans (rs2074192, rs233575, and rs2158083), Australians (rs1978124 and rs2285666), Indians (rs2285666), and Koreans (rs1514282 and rs1514283). A meta-analysis of the association between blood pressure and ACE2 gene polymorphism confirmed that (rs2285666 and rs2106809) are associated with the risk of hypertension in Han subjects 2-5. Therefore, ACE2 genetic variants that play critical roles in high blood pressure have been identified in some countries, but until now, there is not a similar study in Iran. Method: Therefore, in this study, two polymorphisms, rs1978124 and rs2158083, were analyzed in 75 patients with essential hypertension. Data from 75 patients were available for the present study. 52% of the patients were male. The mean (SD) age of the patients was 68.08 years. There were no significant differences in the distribution of gender and age mean between the two groups of hypertensive and hypertensive with other diseases. (P>0.05). All subjects were genotyped with sequencing analysis methods and the correlation between polymorphism, hypertensive, other diseases' severity, were performed using SPSS 20.0. Finding: Based on our results, there was no significant associations were observed between rs2158083 or rs1978124 genotypes and hypertension in either the unadjusted and adjusted models (P>0.05). Conclusion: In conclusion, no significant association was found between the investigated SNPs and hypertension with comorbidities after adjustment for potential confounding factors. Further studies with larger sample sizes are needed to confirm these findings and to clarify the potential role of these polymorphisms in hypertension susceptibility. Keywords: Hypertension, gene polymorphisms, ACE2, renin-angiotensin system, single nucleotide polymorphism