سامانه همایش های دانشگاه آزاد اسلامی واحد نجف آباد

صفحه اصلی / اولین همایش بین المللی تحول خدمات سلامت: تلفیق مراقبت، درمان، بازتوانی و امیدبخشی

Molecular Regulation of Endometrial Angiogenesis by Epigallocatechin Gallate: focusing on Vascular Endothelial Growth Factors and microRNAs

نویسندگان :

Fahimeh Zamani Rarani¹ Bahman Rashidi² Mohammad Zamani rarani³

1- گروه علوم تشریحی و بیولوژی تولید مثل، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران 2- گروه علوم تشریحی و بیولوژی تولید مثل، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران 3- گروه علوم تشریحی، دانشکده ی پزشکی، دانشگاه علوم پزشکی هرمزگان، بندرعباس، ایران

کلمات کلیدی :

Angiogenesis،Endometrium،Epigallocatechin Gallate،Vascular Endothelial Growth Factors،MicroRNAs،Embryo Implantation

چکیده :

Background: Endometrial angiogenesis is essential for endometrial receptivity, embryo implantation, and successful pregnancy, requiring coordinated regulation of angiogenic factors and molecular pathways (1, 2). Epigallocatechin gallate (EGCG) may influence endometrial angiogenesis and contribute to the establishment of a favorable endometrial environment for implantation (3, 4). This article reviews the molecular mechanisms through which EGCG regulates endometrial angiogenesis and its potential implications for reproductive outcomes. Methods: A narrative review searched PubMed/MEDLINE, Scopus, Web of Science, Embase, and Google Scholar for studies published through June 2026, without language restrictions. Eligible studies addressed EGCG, endometrial angiogenesis, implantation, VEGF, or microRNAs; irrelevant, duplicate, and non-research records were excluded. Findings: Evidence indicated that EGCG may regulate endometrial angiogenesis through the modulation of angiogenic signaling networks involved in vascular remodeling and receptivity. EGCG influences the expression of VEGF and angiogenesis-related microRNAs, such as miR-16-5p (3, 4). VEGF signaling and microRNA-mediated regulation are important determinants of endometrial vascular adaptation (5). Collectively, these findings suggested that EGCG may regulate angiogenesis through interactions with various molecular regulators, such as growth factors and microRNAs. Conclusion: EGCG may represent a promising molecular approach for regulating endometrial angiogenesis and improving endometrial receptivity. However, further studies are required to confirm its therapeutic effects and clinical applications in the field of reproduction.